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Cheap Bivalirudin

Bivalirudin (Angiomax or Angiox, manufactured by The Medicines Company) is a specific and reversible direct thrombin inhibitor.


Bivalirudin is an analogue of the peptide hirudin. It is a specific and reversible direct thrombin inhibitor thats works by binding to the catalytic and anionic exosite of circulating and clot-bound thrombin. It is used as an anticoagulant in percutaneous coronary intervention.


Distribution: Does not bind to plasma proteins.

Metabolism: Partly metabolised by the kidneys.

Excretion: Partially cleared renally and proteolytic cleavage. Elimination half-life (normal renal function): 25 minutes.

Bivalirudin Indications / Bivalirudin Uses

As an anticoagulant in percutaneous coronary intervention.? 

Bivalirudin Adverse Reactions / Bivalirudin Side Effects

Bleeding, hypersensitivity reactions. Hypertension, hypotension, bradycardia, nausea, vomiting, dyspepsia, urinary retention, back pain, headache, inj site pain and anxiety.

Potentially Fatal: Severe anaphylactic reactions which may lead to death.


Information Not Available

Special Precautions

Patients at risk of serious bleeding, recent major surgery or puncture of large vessels or organ biopsy. Hepatic or renal impairment.

Other Drug Interactions

May increase risk of bleeding when used with thrombolytics, oral anticoagulants or drugs that affect platelet function.

Other Interactions

Information Not Available



As an anticoagulant in percutaneous coronary intervention

Adult: 750 mcg/kg by IV inj followed by an infusion of 1.75 mg/kg/hr during procedure and up to 4 hr postprocedure. If needed, may continue infusion at 0.2 mg/kg/hr for up to 20 hr.


Information Not Available

Bivalirudin and Pregnancy

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Bivalirudin and Lactation

Caution when used during Lactation

Bivalirudin and Children

Information Not Available

Bivalirudin and Geriatic

Information Not Available

Bivalirudin and Other Contraindications

Active major bleeding. CrCl <30 ml/min and dialysis-dependent patients


Intravenous: Store unopened vials at 15-30?°C. Store reconstituted vials at 2-8?°C

Lab interference

Information Not Available

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